Representative Historical Investments

Amarin Corporation plc

is a biopharmaceutical company focused on improving the treatment of cardiovascular disease.

(NASDAQ: AMRN)

American Medical Systems Holdings, Inc.

acquired from Pfizer Inc., manufactures and markets devices to surgically treat incontinence and impotence.

(ticker: AMMD)

AppTec Laboratory Services, Inc.

provides analytical testing services to the medical device and biopharmaceutical industries and manufactures protein therapeutics for biopharmaceutical customers.

(acquired by Wuxi PharmaTech, plc NYSE: WX; AppTec renamed WuXi AppTec, Inc.

Atritech, Inc.

focused on developing minimally invasive technologies designed for the prevention of atrial fibrillation related stroke.

(acquired by Boston Scientific Corporation NYSE: BSX)

 

Auspex Pharmaceuticals, Inc.

is a developer of next-generation medicines with improved safety and performance and a pioneer in the targeted application of deuterium chemistry to clinically validated drugs.

(acquired by Teva Pharmceuticals Industries Ltd. NYSE:TEVA)

 

Bausch & Lomb, Inc.

is a global leader in medical and consumer eye health.

(acquired by Valeant Pharmaceuticals International, Inc. NYSE: VRX and TSX:VRX)

CAS MEDICAL SYSTEMS, INC.

was a market leader in non-invasive cerebral oximetry and vital signs patient monitoring.

(acquired by Edwards Lifesciences Corporation NYSE: EW)

Celator Pharmaceuticals, Inc.

is developing new and more effective therapies for cancer based on its proprietary CombiPlex® technology.

(NASDAQ: CPXX)

CNS Therapeutics, Inc.

developed high-quality pharmaceuticals for site-specific delivery to the central nervous system to treat neurological disorders and chronic pain.

(acquired by Mallinckrodt, the Pharmaceuticals business of Covidien, NYSE: COV)

Coley Pharmaceutical Group, Inc.

was a leader in the research and development of Toll-like receptor drugs to modulate the immune system for treating cancer, infectious diseases and asthma/allergy.

(acquired by Pfizer Inc. NYSE: PFE)

Galil Medical Ltd.

is a market leader in cryotherapy systems to treat cancerous and benign conditions.

InnoPharma, Inc.

is a developer of sterile generic and specialty pharmaceutical products.

Invitae Corporation

is a company focused on commercial applications of next generation sequencing.

 

(NYSE: NVTA; formerly Locus Development, Inc.)                                      



The Medicines Company

is a licensing-focused, drug development company currently marketing Angiomax™, a novel anti-coagulant.

(NASDAQ: MDCO)

OsteoBiologics, Inc.

developed and marketed bioabsorbable, polymer scaffolds for the treatment of articular cartilage and bone defects.

(acquired by Smith & Nephew plc NYSE: SNN)

PCI Pharma Services, Inc.

is the largest global pharmaceutical contract packager, providing cutting-edge customized healthcare packaging solutions that improve patient adherence and uphold the most stringent safety requirements

Torax Medical, Inc.

developed an implantable device to strengthen the esophageal sphincter for the treatment of gastro-esophogeal reflux disease (GERD).

(acquired by Ethicon, Inc., a Johnson & Johnson company NYSE: JNJ)

Vertiflex, Inc.

developed a less invasive, next generation interspinous spacer for the treatment of lumbar spinal stenosis.

(acquired by Boston Scientific NYSE: BSX)

Wright Medical Group, Inc.

manufactures and markets a full line of orthopedic implants with leading shares of the small joint replacement and biologically active bone void filler markets.
(ticker: WMGI)

Xomed Surgical Products, Inc.

was acquired from Bristol-Myers Squibb Company, and manufactured and marketed products for the treatment of ear, nose and throat diseases.

(acquired by Medtronic, Inc. NYSE: MDT)

Zogenix, Inc.

is a specialty pharmaceutical company focused on the development and commercialization of medicines to treat CNS disorders and pain, with an initial focus on SUMAVEL™ DosePro™, a needle-free migraine treatment.

(NASDAQ: ZGNX)