Representative Historical Investments

Amarin Corporation plc

is a biopharmaceutical company focused on improving the treatment of cardiovascular disease.

(NASDAQ: AMRN)

American Medical Systems Holdings, Inc.

acquired from Pfizer Inc., manufactures and markets devices to surgically treat incontinence and impotence.

(ticker: AMMD)

AppTec Laboratory Services, Inc.

provides analytical testing services to the medical device and biopharmaceutical industries and manufactures protein therapeutics for biopharmaceutical customers.

(acquired by Wuxi PharmaTech, plc NYSE: WX; AppTec renamed WuXi AppTec, Inc.

Atritech, Inc.

focused on developing minimally invasive technologies designed for the prevention of atrial fibrillation related stroke.

(acquired by Boston Scientific Corporation NYSE: BSX)

 

Auspex Pharmaceuticals, Inc.

is a developer of next-generation medicines with improved safety and performance and a pioneer in the targeted application of deuterium chemistry to clinically validated drugs.

(NASDAQ: ASPX)

 

AxioMed Spine Corporation

 developed a next generation, implantable, artificial disc employing state of the art polymer technology.

Bausch & Lomb, Inc.

is a global leader in medical and consumer eye health.

(acquired by Valeant Pharmaceuticals International, Inc. NYSE: VRX and TSX:VRX)

Cebix, Inc.

focused on the development of replacement therapy based on human C-peptide for the treatment of type 1 diabetic neuropathy.

Celator Pharmaceuticals, Inc.

is developing new and more effective therapies for cancer based on its proprietary CombiPlex® technology.

(NASDAQ: CPXX)

CNS Therapeutics, Inc.

developed high-quality pharmaceuticals for site-specific delivery to the central nervous system to treat neurological disorders and chronic pain.

(acquired by Mallinckrodt, the Pharmaceuticals business of Covidien, NYSE: COV)

Coley Pharmaceutical Group, Inc.

was a leader in the research and development of Toll-like receptor drugs to modulate the immune system for treating cancer, infectious diseases and asthma/allergy.

(ticker was COLY; acquired by Pfizer Inc. NYSE: PFE)

Galil Medical Ltd.

is a market leader in cryotherapy systems to treat cancerous and benign conditions.

InnoPharma, Inc.

is a developer of sterile generic and specialty pharmaceutical products.

The Medicines Company

is a licensing-focused, drug development company currently marketing Angiomax™, a novel anti-coagulant.

(ticker: MDCO)

OsteoBiologics, Inc.

developed and marketed bioabsorbable, polymer scaffolds for the treatment of articular cartilage and bone defects.

(acquired by Smith & Nephew plc NYSE: SNN)

Ocera Therapeutics, Inc.

is focused on the development of pharmaceutical products for gastrointestinal and liver diseases.

(NASDAQ: OCRX)

 

Oriel Therapeutics, Inc.

developed dry powder delivery systems for the treatment of asthma and COPD.

(acquired by Sandoz, a division of Novartis AG, NYSE: NVS)

Packaging Coordinators, Inc.

is the largest global pharmaceutical contract packager, providing cutting-edge customized healthcare packaging solutions that improve patient adherence and uphold the most stringent safety requirements

Tranzyme Pharma, Inc.

a clinical-stage biopharmaceutical company that developed novel, small molecule therapeutics for the treatment of gastrointestinal and motility disorders.

(merged with Ocera Therapeutics, Inc. NASDAQ: OCRX)

Virdante Pharmaceuticals , Inc.

focused on the development and commercialization of drugs for autoimmune and inflammatory disorders.

(acquired by Momenta Pharmaceuticals, Inc. NASDAQ: MNTA)

Wright Medical Group, Inc.

manufactures and markets a full line of orthopedic implants with leading shares of the small joint replacement and biologically active bone void filler markets.
(ticker: WMGI)

Xomed Surgical Products, Inc.

was acquired from Bristol-Myers Squibb Company, and manufactured and marketed products for the treatment of ear, nose and throat diseases.

(ticker was XOMD; acquired by Medtronic, Inc. ticker: MDT)

Zogenix, Inc.

is a specialty pharmaceutical company focused on the development and commercialization of medicines to treat CNS disorders and pain, with an initial focus on SUMAVEL™ DosePro™, a needle-free migraine treatment.

(NASDAQ: ZGNX)

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